Valproate - A Standard Drug with a Broad Spectrum of Indications

BRANDNEW - contact your local Desitin organisation.

Valproate exhibits e.g. anticonvulsant, mood-stabilizing and antimanic activities; it has also shown tumor inhibitory effects in clinical studies. It is not only effective for all forms of epilepsy but also still represents the gold standard for primary generalized seizures, as has been impressively demonstrated in recent studies.

Thus, Valproate is a proven classic medication, its broad spectrum of indications ensuring its firm position in the future as well. This booklet written by Günther Krämer M.D., medical director of the Swiss Epilepsy Center in Zurich, presents a comprehensive and most up-to-date overview of the treatment with Valproate, see table of contents.

This 64-page paperback will be available free of charge. You can ask your local Desitin representative for a copy from July 2010 onwards.

Table of Contents

5 Foreword

6 Chemistry and Pharmacology of Valproate

6 Chemistry

6 Activity

7 Pharmacokinetics

12 Valproate in Epilepsy

13 Early Studies with Valproate

13 Idiopathic Epilepsies with Primary Generalized Seizures and Symptomatic Epilepsies with Generalized Seizures

16 Symptomatic and Presumed Symptomatic (Cryptogenic) Epilepsies with Focal Seizures (with or without Secondary Generalization)

21 Add-On Therapy for Focal Epilepsies in Comparison to Placebo

23 Add-On Therapy for Focal Epilepsies in Comparison to Other Antiepileptic Drugs

23 Cochrane Analysis

24 Valproate in Comparison to New Antiepileptic Drugs

24 Valproate versus Oxcarbazepine

24 Valproate versus Lamotrigine

25 Valproate versus Topiramate

25 Benefit-Risk Profile for Valproate in Focal Epilepsies

27 Valproate in Children

27 Valproate in Elderly Patients

28 Valproate for Status Epilepticus